Functionality of hypoxia-induced BAX expression in a human glioblastoma xenograft model

Expression of Cell Surface Receptors on Human Glioblastoma Xenograft Model in NOD/SCID Mouse.

PURPOSE To obtain basic data for development of a glioblastoma-specific immunotoxin, the expression of variable cell surface receptors on a human glioblastoma xenograft model was evaluated, using NOD/SCID mice. MATERIALS AND METHODS We developed a xenograft model in NOD/SCID mice implanted with a human glioblastoma cell line (U-87MG). Immunohistochemical studies were performed on implanted tu...

The Regression of Glioblastoma Multiforme is Time Dependent in Wild-Type Rat Xenograft Model

Introduction: Glioblastoma multiforme (GBM) is an aggressive case of primary brain cancer which remains among the most fatal tumors worldwide. Although, some in vitro and in vivo models have been developed for a better understanding of GBM behavior; a natural model of GBM would improve the efficiency of experimental models to human GBM tumors. We aimed at the present study to examine the surviv...

Tumor response of temozolomide in combination with morphine in a xenograft model of human glioblastoma

Despite multimodal treatments comprising, radiation therapy (RT) and chemotherapy with temozolomide (TMZ), the prognosis of glioblastoma multiforme (GBM) remains dismal and consolidated therapy yields a median survival of 14.6 months. Blood Brain Barrier (BBB) mediated chemoresistance and high dose related toxicity make necessary the development of new therapeutic approach to sensitize GBM to T...

Gene expression quantification of toll like receptors 2, 4 and co-molecules in human glioblastoma Cell Line (U87-MG): Toward a New In vitro Model of Inflammation

The effect of extract of Dunaliella salina L. on the expression of Bax in glioblastoma cancer cell Line

Background & Aims: Plant extracts can change the expression of genes in cancer cells. Till now, no study has been performed on the effect of algae extract. The aim of this research was to study the changes in Bax apoptotic gene expression in glioblastoma cell line and to determine the rate of cell death in cancer cells treated with Dunalilla salina extract. U87 cell line contains glioblas...